他汀类降低房颤风险

Statins Linked to Reduced Prevalence of Atrial Fibrillation in Patients With ACS
他汀类可以降低急性冠脉综合征患者的房颤发病率
NEW YORK (Reuters Health) Sept 13 - Patients presenting with symptoms of acute coronary syndrome (ACS) are less likely to develop new-onset atrial fibrillation (AF) if they are being treated with a statin, study results suggest.
纽约9.13-研究结果显示：具有急性冠脉综合征症状的患者如果应用他汀类药物，其新发房颤的可能性较小。

Dr. Maliha Zahid at the University of Pittsburgh and associates examined the medical records of patients with suspected ACS admitted to the Veterans Administration Hospital in Pittsburgh between 2001 and 2006. Their study cohort included 1,526 patients, of whom 138 had new onset of AF; 601 were on statins.
匹兹堡大学的Maliha Zahid博士及其同事，研究了2001-2006中匹兹堡复员军人管理局医院的可疑为急性冠脉综合征患者的病例资料。这组研究对象共有1526名患者，其中138名有新发的房颤，601名经受他汀类药物治疗。
Patients on statins were significantly less likely to have new-onset AF (adjusted odds ratio 0.57, p < 0.001), the team reports in the August issue of the American Journal of Cardiology.
该研究小组在8月份美国心脏病杂志报告：接受他汀类药物治疗的患者的新发房颤率明显下降（OR0.57, p < 0.001)。
Their analyses also showed that renal failure and age over 65 years were significantly associated with increased risk of developing AF (OR 1.89 and 1.58, respectively). Factors that significantly reduced AF onset included chest pain (OR 0.35), non-Caucasian race (OR 0.61), diabetes (OR 0.67) and ACE inhibitor use (OR 0.63).
他们的分析结果还显示：肾衰和高龄（>65岁）可以明显的增加房颤的发病（OR 1.89 ， 1.58）。而那些能降低房颤发病的因素有胸痛(OR 0.35), 非白种人(OR 0.61), 糖尿病 (OR 0.67) 和 血管紧张素转换酶抑制剂的应用(OR 0.63)。
The investigators suggest that the reduced risk associated with diabetes \"is potentially related to the fact that patients with diabetes receive more aggressive medical care and superior blood pressure control, specifically with ACE inhibitors and angiotensin II receptor blockers, which decrease the incidence of AF.\"
研究者认为糖尿病之所以与降低房颤发病率，可能是因为糖尿病患者接受强有力的药物治疗以及较好的控制了血压，特别是管紧张素转换酶抑制剂和血管紧张素Ⅱ阻断剂的使用，而后者可以有效的降低房颤的发生。
In regards to the decreased risk of AF related to chest pain, they believe that clinicians are more likely to suspect ACS in the presence of chest pain, and therefore start treatment earlier.
关于胸痛能够降低房颤的危险，他们相信是临床医生在发现患者有胸痛症状时，会高度怀疑急性冠脉综合征，因此较早的给予了 治疗。
初步翻译： 他汀类可以降低急性冠脉综合征患者的房颤发病率
纽约9.13-研究结果显示：具有急性冠脉综合征症状的患者如果应用他汀类药物，其新发房颤的可能性较小。匹兹堡大学的Maliha Zahid博士及其同事，研究了2001-2006中匹兹堡复员军人管理局医院的可疑为急性冠脉综合征患者的病例资料。这组研究对象共有1526名患者，其中138名有新发的房颤，601名经受他汀类药物治疗该研究小组在8月份美国心脏病杂志报告：接受他汀类药物治疗的患者的新发房颤率明显下降（OR0.57, p < 0.001)。他们的分析结果还显示：肾衰和高龄（>65岁）可以明显的增加房颤的发病（OR 1.89 ， 1.58）。而那些能降低房颤发病的因素有胸痛(OR 0.35), 非白种人(OR 0.61), 糖尿病 (OR 0.67) 和 血管紧张素转换酶抑制剂的应用(OR 0.63)。研究者认为糖尿病之所以与降低房颤发病率，可能是因为糖尿病患者接受强有力的药物治疗以及较好的控制了血压，特别是管紧张素转换酶抑制剂和血管紧张素Ⅱ阻断剂的使用，而后者可以有效的降低房颤的发生。关于胸痛能够降低房颤的危险，他们相信是临床医生在发现患者有胸痛症状时，会高度怀疑急性冠脉综合征，因此较早的给予了 治疗。