普通基因缺陷增加中风风险

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普通基因缺陷增加中风风险
美国东部时间 2007年3月28日 上午12：00
WEDNESDAY, March 28 (HealthDay News) -- A common genetic defect can significantly increase a person's risk for stroke, Danish researchers report.
The 24-year study included almost 9,200 people, 393 of whom had a stroke and 504 of whom developed cerebrovascular disease during the study period.
每日健康新闻3月28日（星期三）报道：丹麦研究人员称一个普通基因缺陷能明显增加中风风险。在一项历时24年包括9200人的研究中，研究期内有393名发生中风，504名发生脑血管疾病。
Reporting in the March 27 issue of Neurology, researchers found that people with two copies of the H63D genetic defect in the HFE gene were two to three times more likely to have a stroke than people without the defect.
研究人员发现在HFE基因上有两个H63D遗传缺陷的人患中风的风险是没有基因缺陷人的2到3倍。这项研究结果发表在《神经病学》3月27日刊上。
It's estimated that about 25 percent of northern Europeans carry the H63D gene defect, and it may be even more common in southern Europeans.
据估计，大约25%的北欧人有H63D 基因缺陷，在南欧人中可能更多。
\"This type of gene has previously been associated with brain diseases such as Alzheimer's disease, Parkinson's disease, ALS, multiple sclerosis and cerebrovascular disease, but this is the first time we've been able to determine this gene predicts such a significant increased risk of stroke,\" study author Dr. Borge G. Nordestgaard, of Herlev University Hospital in Copenhagen, said in a prepared statement.
“这种基因先前证明与阿尔茨海默病、帕金森病、肌萎缩性侧索硬化症、多发性硬化和脑血管疾病等脑疾病有关，但是我们首次确定这个基因预示着中风风险增加。” 研究作者、哥本哈根海莱乌大学医院Borge G. Nordestgaard,博士在一个声明中说。
The genetic defect was not associated with carotid atherosclerosis (hardening of the arteries in the neck and head), the researchers said.
这个基因缺陷与颈动脉粥样硬化（颈部和头部动脉硬化）没有关系，研究人员说。
Further research is needed to determine why this genetic defect appears to cause such a significant increase in stroke, they added.
我们需要进一步的研究来确定为什么这个基因缺陷引起中风风险明显增加，他们补充说。
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The U.S. National Institute of Neurological Disorders and Stroke outlines stroke risk factors and symptoms.
美国国立神经疾病和中风研究所 中风危险因素和症状