Fish Helps Statins Protect the Heart

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Fish Helps Statins Protect the Heart
吃鱼可以协同他汀类药物保护心脏
By Steven Reinberg
HealthDay Reporter
Friday, March 30, 2007; 12:00 AM
每日健康记者Steven Reinberg
2007-3-30 星期五 上午12:00
FRIDAY, March 30 (HealthDay News) -- People taking cholesterol-lowering drugs called statins who also consume omega-3 fatty acids -- typically found in fish and fish oil -- have a better chance of avoiding heart problems than patients who take statins alone.
3月30号星期五，每日健康新闻报道：与单独服用他汀类药物相比，人们服用降低胆固醇的他汀类药物的同时服用一种在鱼和鱼油中发现的n-3脂肪酸能更有效避免心脏问题的发生。
That's the conclusion of a new study by Japanese researchers that is published in the March 31 issue ofThe Lancet.
这一项新的研究结论将由日本科学家发表于3月31号的《柳叶刀》上。
\"Our study shows that long-term use of EPA (an omega-3 fatty acid) at therapeutic doses is effective for prevention of major coronary events in hypercholesterolemia (high cholesterol) patients given statins in Japan who consume a large amount of fish,\" said lead researcher Dr. Mitsuhiro Yokoyama. He is a professor of medicine at the Kobe University Graduate School of Medicine.
我们的研究显示以治疗剂量长期使用二十碳五烯酸（一种n-3脂肪酸）能有效预防高胆固醇血症病人主要冠状动脉事件发生，在日本，食用大量鱼的这些病人只需单独服用他汀类药物、神户大学医学研究生院首席研究员，医学教授Mitsuhiro Yokoyama博士说。
In the study, called the Japan EPA Lipid Intervention Study, Yokoyama and his colleagues assigned 18,645 people to receive either 1,800 milligrams of one of the omega-3 fatty acids, eicosapentaenoic acid (EPA), every day plus a statin, or a statin alone.
在这项名为日本二十碳五烯酸脂质干预性研究中，Yokoyama和他的同事们选定了18，645人，其中一组接受每天1800毫克的n-3脂肪酸，二十碳五烯酸(EPA)加上一种他汀类药，另一组只用一种他汀类药物。
During an average follow-up of 4.6 years, the researchers found a 19 percent reduction in major coronary events among patients taking EPA. Patients taking EPA also had 19 percent fewer non-fatal events -- including non-fatal heart attack, unstable angina, and coronary revascularization -- than people taking statins alone. However, the incidence of sudden cardiac death and death from heart disease did not differ between the groups.
在平均随访的4.6年时间里，研究者发现在服用EPA的人群中，主冠状动脉事件发生率降低19%；非致命事件包括非致命心脏病发作，不稳定型心绞痛，冠状动脉重建术的发生率较单独服用他汀类药物的人群减少19%。但是，心脏猝死的发生率和心脏病死亡率之间没有差别。
The preventive effects of EPA are of both clinical interest and therapeutic importance, Yokoyama said. \"EPA is thought to exert its plaque-stabilization effect via mechanisms that are independent of a reduction in cholesterol,\" he added.
这种预防作用在理论和临床应用方面均有重要意义， Yokoyama说：“EPA通过一种不依赖于胆固醇浓度的机制发挥稳定修饰作用”。

Sickness and death from coronary artery disease is very low in Japan in comparison with the United States and northern Europe, Yokoyama said. \"This difference might be explained partly due to differences in dietary habits, including fish consumption. We want to know whether our results can be generalized to other populations who consume a small intake of fish and have very high mortality from coronary artery disease,\" he said.
在日本，冠脉病变诱发的心脏疾病及卒中事件远远低于美欧。Yokoyama说：“这种差异部分可以用饮食结构的差异来解释，其中鱼类食物的消费也包含与内。我们想知道我们的研究结果在鱼类食品低消费和冠脉疾病高发病率的种群是否依然适用”他说。
One expert thinks the study results aren't surprising, but they are interesting, because the research was done in a country where people eat more fish than they do in the United States.
一位专家说，研究结果并非出乎意料，但是他们感兴趣的是，这个试验选择了一个鱼类消费量高于美国的地区进行。
\"This study is further evidence of the benefit of omega-3 fatty acids for protecting against heart attacks and other cardiac events,\" said Dr. Dariush Mozaffarian, an assistant professor of epidemiology at Harvard Medical School and Harvard School of Public Health, and author of an accompanying editorial in the journal.
“此研究进一步证明了n-3脂肪酸在防治心脏病方面有一定的保护作用。”Dariush Mozaffarian博士说，他是哈佛大学医学部流行病学助理教授，《哈佛大学公共卫生学学报》主编评论作者。
Mozaffarian said that the trial was done, in part, to see if combining EPA with a statin could be effective in reducing cardiac events.
Mozaffarian说， 此项试验一部分是为了研究EPA与他汀类药物联合应用是否可以有效的降低心脏病事件的发生率。
While there did appear to be a benefit in taking EPA, coupling it with a statin in one pill isn't necessary, Mozaffarian said. \"The pharmaceutical manufacturers are facing the end of patents on their statins,\" he said. \"The idea of putting a statin and EPA in a single pill is really just marketing,\" he added.
虽然服用EPA可以从中获益，但是把它与他汀药物联合制成片剂并非必要, Mozaffarian说：“药物制造商正准备为这种特殊制备的他汀药物申请专利，这种把他汀药物和EPA融合于一体的片剂即将上市”。Mozaffarian noted that a healthful diet should provide enough EPA to reduce the risk of heart trouble. \"eople should be able to get a cardioprotective dose of omega-3 fatty acids by eating fish twice a week,\" he said.
MOzaffarin指出，“健康的饮食应该包含足够的EPA以降低心脏疾病的风险。如果人们一周吃两顿鱼，就应该能获得心脏保护剂量的n-3脂肪酸。 ”