A prospective study of overall diet quality and risk of type 2 diabetes in wo

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TITLE:A prospective study of overall diet quality and risk of type 2 diabetes in women
题目：有关女性患2型糖尿病与总体膳食质量的一项前瞻性研究
AUTHOR:
作者：Teresa T. Fung, ScD, Marjorie McCullough, ScD, Rob M. van Dam, PhD and Frank B. Hu, MD, PhD
RESOURCEiabetes Care Publish Ahead of Print published online ahead of print April 11, 2007

ABSTRACT:
摘要：
Objectives:To assess the association between the Alternate Healthy Eating Index (AHEI) and risk of type 2 diabetes in women.
目的：评估女性健康饮食与2型糖尿病风险之间的关系
Research design and methods:80,029 women aged 38-63 in the Nurses' Health Study were followed from 1984 to 2002. The AHEI score was computed from dietary information collected from five repeated food frequency questionnaires administered between 1984 and 1998. Relative risks for type 2 diabetes were calculated using Cox proportional hazards models and adjusted for known diabetes risk factors. We also examined how changes in score in 4, 6-8, and 10--12 years are associated with diabetes risk.
实验设计和方法：实验对象为1984-2002年护理健康研究所80029位38-63岁之间的妇女。1984-1998年五次重复填写了食物频率调查表，并用计算机对所搜集的信息进行了整理得出AHEI得分。用Cox风险比率模型对2型糖尿病相关危险因素进行了整理并用已知危险因素对数据进行了矫正。我们还分析了积分在4分、6-8分、以及10-12分的人群中2型糖尿病患病风险的差异。
Results:We ascertained 5,183 incident cases of type 2 diabetes during 18 years of follow-up. Women who scored high on the AHEI were at lower risk (relative risk comparing top to bottom score quintile=0.64 (95%CI=0.58-0.71, p trend <0.0001) for diabetes. Women with consistently high AHEI scores throughout follow-up, compared with those with consistently low scores, were at the lowest risk for diabetes. In addition, women whose AHEI scores improved during follow-up, even during recent years, were at lower risk of diabetes than were women whose (low) score did not change.
结果：根据长达18年的调查研究我们得出了5183项与2型糖尿病相关的可能因素。在调查中AHEL得分较低的女性患2型糖尿病的风险较低（相关风险四分位数为0.64，可信区间0.58-0.71，p值小于0.0001）那些在整个调查过程中保持较高AHEI值的女性比一直以来AHEI得分较低的女性患2型糖尿病的风险低很多。而且，在后期调查中AHEI升高的女性的患病风险也低于那些一直保持低值的女性。
Conclusions:A higher AHEI score is associated with lower risk of type 2 diabetes in women. Therefore, the AHEI score maybe a useful clinical tool to assess diet quality and to recommend for the prevention of diabetes.
结论：AHEI高值与2型糖尿病地发病率相关。所以，AHEI得分可能是一个有用的临床评价饮食质量的指标，并可以用来做预防糖尿病饮食的指导。