肝脏在代谢综合征中作用的研究观点

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Research Offers Insights Into Liver's Role in Metabolic Syndrome
The organ seems to influence blood pressure variation in Hispanic-Americans

HealthDay

By Robert Preidt

Thursday, October 5, 2006

THURSDAY, Oct. 5 (HealthDay News) -- Liver function influences blood pressure variation in non-diabetic Hispanic-American families, according to a study presented Thursday at a meeting of the American Heart Association.

The liver is known to play an important role in metabolic syndrome, a condition that features insulin resistance, obesity, diabetes, high blood pressure, and lipid abnormalities. While much still needs to be learned about how all these conditions are interrelated, it is known that insulin resistance influences blood pressure, according to a news release about the study.

In previous work, the U.S. researchers identified both physiological and genetic links between insulin resistance and liver enzymes. In this new study, they examined the link between liver function and blood pressure in 635 non-diabetic Hispanic-Americans who had a parent with high blood pressure.

The study volunteers had liver function tests and were checked for a number of factors that influence blood pressure, including age, sex, body weight, insulin resistance, lipids, and thickness of the wall of the carotid artery.

The researchers identified combinations of liver function tests that are significant predictors for systolic blood pressure -- the top number in a blood pressure reading. They also found that carotid artery thickness, sex, weight, and insulin resistance were linked to systolic pressure.

The liver tests did not predict diastolic blood pressure, which is the lower number in a blood pressure reading. Age, sex, and insulin resistance influenced that number, the study found.

The study authors said further research is needed to better understand the role of the liver in blood pressure and other features of metabolic syndrome.

The findings were presented at the American Heart Association's 60th Annual High Blood Pressure Research Conference, in San Antonio.
肝脏在代谢综合征中作用的研究观点
肝脏可能影响了西班牙裔美国人中的血压变化

健康日报
作者：Robert Preidt
星期四，10.5,2006

星期四，10.5(健康日报)　　在美国心脏协会组织的一次会议上，一份研究报告指出：肝脏功能影响了非糖尿病西班牙裔美国人家庭中的血压变化。

众所周知，肝脏在代谢综合征中扮演了重要的角色，这种代谢综合征以胰岛素抵抗，肥胖，糖尿病，高血压和脂质代谢紊乱为特征。然而，关于这些综合征之间的相互关联却知之甚少，通过本项研究则可以了解到胰岛素抵抗能够影响血压变化。

在之前的工作中，美国研究人员确认了胰岛素抵抗和肝酶之间的生理及基因联系。而在这项新的研究中，研究人员检测了６３５例非糖尿病的西班牙裔美国人中肝脏功能和血压之间的联系，在这些美国人中都有一位父母患有高血压。

研究志愿者检查了肝功能和一系列影响血压的因素，包括年龄，性别，体重，胰岛素抵抗，脂质以及颈动脉壁的厚度。

研究人员确认肝功能检查的综合结果可以用来预测收缩压（血压读数计里的最高值）。同时，他们也发现颈动脉壁厚度，性别，体重和胰岛素抵抗也和收缩压相关。

肝脏功能检测不能预测舒张压（血压读数计中的较低值）。但研究发现，年龄、性别和胰岛素抵抗能影响舒张压。

研究者称需要对肝脏在血压和其他代谢综合征中的作用进行深入研究。

这些发现已经发表在美国心脏协会第６０届年会的高血压研讨会上，本次年会在圣安东尼奥举行。

注：代谢综合征亦称胰岛素抗拒症候群。当一个人同时具有以下3 项或
更多的状况，即腹部肥胖、高水平的三酸甘油脂、低水平的高密度脂肪
酸(HDL)、高血压以及禁食后仍然偏高的血糖水平，就会被诊断为代谢症
候群。