Screening of 5-HT1A Receptor Antagonists using Molecularly Imprinted Polymers

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Title：Screening of 5-HT1A Receptor Antagonists using Molecularly Imprinted Polymers
標題：分子印跡聚合物篩選5-羥色胺受體拮抗劑
Author：Naphtali A. O'Connor, David A. Paisner, Donna Huryn, and Kenneth J. Shea
作者：Naphtali A. O'Connor, David A. Paisner, Donna Huryn, and Kenneth J. Shea
Resource: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007，129 （6）:1680 -1689.
文章来源：美国化学杂志, 2007，129 （6）:1680 -1689.
Abstract：Molecular imprinting produces network polymers with recognition sites for imprint molecules.
摘要：
分子印记技术可以生产带有印迹分子识别位点的网状聚合物。
The high binding affinity and selectivity in conjunction with the polymers' physical robustness positions molecular imprinted polymers (MIPs) as candidates for use as preliminary screens in drug discovery.
做为初步筛选新药的方法，当与聚合物物理骨架中放置的分子印迹聚合物(MIPs)相结合时会有高亲和力和高选择性。

As such, MIPs can serve as crude mimics of native receptors. In an effort to evaluate the relationship between MIPs and native receptors, imprinted polymers for WAY-100635, an antagonist of the serotonin (5-HT) receptor subtype 5-HT1A were prepared.
如此，MIPs可以做为自然受体的相似物。在试图评估MIPs和自然受体间关系时，一种5-羟色胺(5-HT)受体亚型5-HT1A拮抗剂WAY-100635的印迹聚合物被制备出来。
The resulting MIP P(WAY) was evaluated as an affinity matrix in the screening of serotonin receptor antagonists with known affinities for the native receptor.
结果产物MIP P(WAY) 在筛选与自然受体有亲和力的5-羟色胺受体拮抗剂中被评价为一种亲和基质。
Rough correlations in affinity between the synthetic P(WAY) and native receptor 5-HT1A were found. These findings provide some support for the analogy between MIPs and native receptors and their possible use as surrogates.
已经发现了合成P(WAY)和天然受体5-HT1A间亲和力的基本联系。这些发现结果为类推MIPs和天然受体及其可能代用品间关系提供了一些支持。