Management of Chronic Obstructive Pulmonary Disease (European Respiratory Mon

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Management of Chronic Obstructive Pulmonary Disease
(European Respiratory Monograph)

European Respiratory Society (ERS)
Published Dec 2006
480 pages
pdf file

The present, new edition of the European Respiratory Monograph on the
\"Management of Chronic Obstructive Pulmonary Disease\", introduces new developments in
the area of chronic obstructive pulmonary disease (COPD) since the first edition in
1998. Since 1998, two major international guidelines for the management of COPD
have been published: the Global Initiative for Chronic Obstructive Lung Disease
(GOLD) in 2001 and the guidelines of the American Thoracic Society/European
Respiratory Society (ERS) Task Force in 2004. Even the definition of the disease has changed
since 1998 and now incorporates aetiological factors (smoking), pathogenetic mechanisms
(inflammation), early staging (GOLD stage 0), and systemic consequences and optimistic views
that the disease is preventable and treatable.
Over the past 8 yrs, significant developments concerning the pathogenesis of
the disease have emerged; for example, inflammatory pathways, apoptosis,
impaired remodelling etc. In addition, various cell types have been shown to play a
key role in the pathogenesis, such as CD8zlymphocytes, dendritic cells, type II
pneumocytes and epithelial cells. The genetic background of the disease has also been
extensively investigated.
Moreover, new significant modes of treatment have become available and have
had to be incorporated into this second edition. An example of this is the new
long-acting anticholinergics. Therefore, most of the original chapters have been
completely rewritten, some have been updated and new chapters have been included.
I am extremely grateful to all the authors who have contributed for their
hard work and for supporting the efforts of the ERS in producing high-quality,
comprehensive European Respiratory Monographs for its members. However,
this Monograph is primarily designed for clinicians and fellows in training.
I do hope that reading this European Respiratory Monograph \"Management of
Chronic Obstructive Pulmonary Disease\", a disease that still is a leading
cause of morbidity and mortality in the world, will give the interested reader the
appropriate data and as much pleasure as I had when editing it.

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