Chromatin and Disease (Subcellular Biochemistry)

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Publisher:  Springer
Number Of Pages:  300
Publication Date:  2007-01
Sales Rank:  3580305
ISBN / ASIN:  1402054653
EAN:  9781402054655
Binding:  Hardcover
Manufacturer:  Springer
Studio:  Springer
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About this book

The packaging of genomic DNA together with core histones, linker histones, and other functional proteins into chromatin play key roles in nuclear processes such as transcription, replication, repair and recombination. Research in the last two decades has unveiled the fact that many diseases involve an aberration of these processes at the chromatin level.

Similarly, it is becoming clear that different processes such as chromatin assembly, remodeling of chromatin structure coupled to covalent modification of read.freeduan.com histone and non-histone proteins, chromatin modifying enzymes and important DNA-templated phenomena are the potential drug targets for diseases such as different types of cancer, neurodegenrative diseases, AIDS etc. While the earliest form of chemotherapy employed chromosomal DNA cleavage and modification, the study of epigenetic functions and therapy has recently emerged as a frontline research activity.

At this juncture we felt the necessity to make an overview of the current research activities in the above areas. It is obvious that this collection starts with our current knowledge of chromatin structure. This work is the first endeavor to present different aspects encompassing the above theme.

Written for:
Undergraduate students, as well as the research community

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Table of contents
PART I: Chromatin Structure, Dynamics and Disease

1 Structural organization of dynamic chromatin in humans.
Kohji Hizume, Shige H. Yoshimura and Kunio Takeyasu

2 Chromatin Remodeling: Action and Reaction.
Parul Choudhary and Patrick Varga-Weisz

3 Regulation of Chromatin Structure and Transcription by Poly (ADP- Ribose) Polymerase- I: Possible targets for drug based therapies.
David A. Wacker, Kristine M. Frizzell, and W. Lee Kraus

4 Histone variant nucleosomes: structure, function and implication in disease.
Mathieu Boulard, Philippe Bouvet, Tapas K Kundu and Stefan Dimitrov

5 Histone variants and complexes involved in their exchange.
Thomas Kusch and Jerry L. Workman

6 Histone chaperones in chromatin dynamics: Implication in disease manifestation.
Jayasha Shandilya, Shrikanth Gadad, V.Swaminathan and Tapas K. Kundu

7 Function of the histone chaperone Nucleolin in diseases.
Sébastien Storck, Manu Shukla, Philippe Bouvet

8 Chromatin as a target for the DNA binding anti-cancer drugs.
Parijat Majumder, Suman K. Pradhan, Pukhrambam Grihanjali Devi, Sudipta Pal and Dipak Dasgupta


PART II: Nonhistone Proteins, Sites for Epigenetic Marks: link to Disease.

9 Reversible acetylation of Non Histone proteins: Role in cellular function and disease.
Kiran Batta, Chandrima Das, Shrikanth Gadad, Jayasha Shandilya and Tapas K. Kundu

10 MARs and MARBPs: Key modulators of gene regulation and disease manifestation.
Samit Chattopadhyay and Lakshminarasimhan Pavithra


PART III : Epigenetic Modifications of Chromatin : Implication in Disease and Therapeutics.

11 Aberrant forms of acetyltransferases in human diseases.
Olivier van Beekum and Eric Kalkhoven

12 Chromatin acetylation status in the manifestation of neurodegenerative diseases: HDAC inhibitors as therapeutic tools?
Anne-Laurence Boutillier, Caroline Rouaux, Panteleeva

13 Function of MYST family Histone acetyltransferases and their link to diseases.
Nikita Avvakumov and Jacques Cote

14 Role of histone phosphorylation in chromatin dynamics and its implication in diseases.
Masaya Oki, Hitoshi Aihara and Takashi Ito

15 Function of euchromatic histone H3K9 methyltransferases, G9a/GLP.
Yoichi Shinkai

16 Histone acetylation and methylation: Combinatorial players for transcriptional regulation
Woojin An

17.Chromatin modifying enzymes and HIV gene expression.
Vincent Quivy, Stéphane de Walque, and Carine Van Lint



18.Small Molecule Modulators in Epigenetics: Implication in gene expression and therapeutics.
V.Swaminathan, B.A.Ashok Reddy, Selvi R, Sukanya.M.S. and Tapas K. Kundu

Index

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