Tissue and Organ Regeneration in Adults

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Tissue and Organ Regeneration in Adults
By Ioannis V. Yannas


Publisher:  Springer
Number Of Pages:  383
Publication Date:  2001-08-09
Sales Rank:  456626
ISBN / ASIN:  0387952144
EAN:  9780387952147
Binding:  Hardcover
Manufacturer:  Springer
Studio:  Springer
Average Rating:  4
Total Reviews:  1


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Book Description:

The emphasis throughout this volume is on the systematic development of the viewpoint that regeneration is an instance of synthesis of tissues and organs. This has three simple consequences. The first is the requirement for a special kind of experimental reactor, free of tissues that do not regenerate spontaneously. The second calls for meticulous physicochemical and biological characterization of the end products from such a synthetic reaction. The third calls for the required use of appropriate non-diffusible regulators in the experimental reactor. These insoluble matrices induce adult cells to abandon their normal proclivity in closing up adult wounds in exchange for synthesizing physiological tissues. This approach is independent of the organ under study. It is developed in substantial depth during the first several chapters by limiting the discussion to just two two organs that are quite different from each other, namely skin and peripheral nerves. The conclusions from this analysis apply to either organ with roughly equal strength. This intriguing result clearly suggests a generic methodology for synthesis of other organs. The book also features an extensive bibliography, and extensive bodies of independent data on organ regeneration from the journal literature have been collected together for the first time and accessibly presented in tabular form, enabling direct comparisons. In short, the generic organ-blind methodology described in this volume should be useful to most students and practitioners of tissue engineering.





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Date: 2002-12-11  Rating: 4
Review:
Good compilation of material from MIT courses

This unique book represents a compilation of material presented by Prof. Yannas over a couple of courses at MIT. The material is clearly presented and will probably be best used by graduate students and experimentalists in the field. This book is not a list of protocols. It is a review of the field and a summary of the Yannas lab's impressive body of work in the areas of skin and nerve tissue regeneration.