Histone Deacetylases: Transcriptional Regulation and Other Cellular Functions

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Histone Deacetylases: Transcriptional Regulation and Other Cellular Functions (Cancer Drug Discovery and Development)
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Publisher:  Humana Press
Number Of Pages:  352
Publication Date:  2006-01-05
Sales Rank:  1837606
ISBN / ASIN:  1588294994
EAN:  9781588294999
Binding:  Hardcover
Manufacturer:  Humana Press
Studio:  Humana Press
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Book Description:

A panel of leading investigators summarizes and synthesizes the new discoveries in the rapidly evolving field of histone acetylation as a key regulatory mechanism for gene expression. The authors describe what has been learned about these proteins, including the identification of the enzymes, the elucidation of the enzymatic mechanisms of action, and the identification of their substrates and their partners. They also review the structures that have been solved for a number of enzymes-both alone and in complex with small molecule inhibitors-and the biological roles of the several histone deacetylases (HDAC) genes that have been knocked out in mice.

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