The Oncogenomics Handbook (Cancer Drug Discovery and Development)

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The Oncogenomics Handbook (Cancer Drug Discovery and Development)
By


Publisher:  Humana Press
Number Of Pages:  768
Publication Date:  2005-04-15
Sales Rank:  2167409
ISBN / ASIN:  1588294250
EAN:  9781588294258
Binding:  Hardcover
Manufacturer:  Humana Press
Studio:  Humana Press
Average Rating:  5
Total Reviews:  1



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Book Description:

An integrated overview of cancer drug discovery and development from the bench to the clinic, showing with broad strokes and representative examples the drug development process as a network of linked components leading from the discovered target to the ultimate therapeutic product. Following a systems biology approach, the authors explain genomic databases and how to discover oncological targets from them, how then to advance from the gene and transcript to the level of protein biochemistry, how next to move from the chemical realm to that of the living cell and, ultimately, pursue animal modeling and clinical development. Emerging cancer therapeutics including Ritux an, Erbitux, Gleevec Herceptin, Avastin, ABX-EGF, Velcade, Kepivance, Iressa, Tarceva, and Zevalin are addressed. Highlights include cancer genomics, pharmacogenomics, transcriptomics, gene expression analysis, proteomic and enzymatic cancer profiling technologies, and cellular and animal approaches to cancer target validation.





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Date: 2005-11-09  Rating: 5
Review:
Thorough Review of Genomics-Based Cancer Research

This work draws on the experience of dozens of leading scientists in the public and private sector in their efforts to use information from genomics to understand and develop cancer therapies. A wide variety of experimental cancer drugs are discussed, and clinical trial data are presented. At 750 pages it is a substantial work, with enough technical detail to suit the bench scientist and physician, yet an easy enough read to be appreciated by the avid learner.


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