[Free Amazon Ebook]Peptide Antibiotics

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ISBN: 082470245X
Title: Peptide Antibiotics
Author:Christopher Dutton (Editor), Mark Haxwell (Editor), Hamish McArthur (Editor), Richard G. Wax (Editor)
Publisher: CRC
Publication Date: 2001-12-04
Number Of Pages: 308

下载地址：
http://rapidshare.de/files/28716410/PA.pdf

Book Description
This reference summarizes the latest research on the structure, function, and design of synthetic and natural peptide antibiotics, describing practical applications of these compounds in food preservation and packaging, and in the prevention and treatment of infectious diseases by direct anti-bacterial action and as part of the adaptive immune response.Peptide Antibiotics discusses these unique compounds and their many and exciting applications, including:the distribution and classification of diverse antimicrobial peptides throughout naturethe role in host defense of mucosal surface peptide antibiotics such as defensins and cathepsinsthe biosynthesis of lanthionine-containing antibiotics including nisin, epidermin, and mersacidinthe genetic basis determining the production of bacterial peptide antibioticsthe potential commercial use of magainin, nisin, and lacticin peptides as anti-infective agentsthe use of nisin as a commercial food preservativeWith contributions from 19 world-renowned experts in the field, Peptide Antibiotics is an indispensable source of information for pharmaceutical scientists, medicinal and organic chemists and biochemists, microbiologists, infectious disease specialists, molecular biologists, and upper-level undergraduate and graduate students in these disciplines.

Book Info
Pfizer Global Research and Development, Sandwich, Kent, UK. Describes the discovery of these novel compounds and the application of biotechnology to many aspects of their development. Summarizes latest research on the structure, function, and design of synthetic and natural peptide antibiotics.

意义:
肽抗生素(Peptide antibiotics) 是昆虫、动物、植物以及人体基因编码的具有抗生素样活性的肽类物质,因其抗菌活性强、且具有抗菌广谱性,在临床感染菌对常规抗生素的耐药性日益严重的今天,肽抗生素的研究得到广泛重视,一方面,人们试图通过研究弄清不同种属动植物肽抗生素的结构、分布、表达的调控机制;另一方面,也是人们最感兴趣的方面,即研究肽抗生素的药用开发价值,努力使之成为继青霉素等传统的抗生素之后又一类新型的抗菌药物。
\"The content of this volume is a testament to the importance of antimicrobial peptides in the lives of all organisms...\"