2型糖尿病和帕金森病的风险

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Title：Type 2 diabetes and the risk of Parkinson's disease.2型糖尿病和帕金森病的风险
Author：Hu G, Jousilahti P, Bidel S, Antikainen R, Tuomilehto J.

Resource: Diabetes Care. 2007 Apr;30(4):842-7.

Abstract：OBJECTIVE: To evaluate whether type 2 diabetes at baseline is a risk factor for Parkinson's disease. 目的：评价2型糖尿病是否是帕金森病的一个危险因子。
RESEARCH DESIGN AND METHODS: We prospectively followed 51,552 Finnish men and women 25-74 years of age without a history of Parkinson's disease at baseline. History of diabetes and other study parameters were determined at baseline using standardized measurements. Ascertainment of the Parkinson's disease status was based on the nationwide Social Insurance Institution's drug register data. Hazard ratios of incident Parkinson's disease associated with the history of type 2 diabetes were estimated.实验设计和方法：我们前瞻性的随访作为基线的51552个25-74岁无帕金森病史的芬兰男人和女人.糖尿病史和其它研究参数通过标准化方法在基线被确定。帕金森病的确诊是根据全国性的社会保险协会的药物登记信息。伴有2型糖尿病的帕金森病人的危害率可以评价出来。
RESULTS: During a mean follow-up period of 18.0 years, 324 men and 309 women developed incident Parkinson's disease. Age- and study year-adjusted hazard ratios of incident Parkinson's disease among subjects with type 2 diabetes, compared with those without it, were 1.80 (95% CI 1.03-3.15) in men, 1.93 (1.05-3.53) in women, and 1.85 (1.23-2.80) in men and women combined (adjusted also for sex). Further adjustment for BMI, systolic blood pressure, total cholesterol, education, leisure-time physical activity, smoking, alcohol drinking, and coffee and tea consumption affected the results only slightly. The multivariate adjusted association between type 2 diabetes and the risk of Parkinson's disease was also confirmed in stratified subgroup analysis. 结果：在平均18.0年的随访时间中，324位男人和309位女人发展为帕金森病。患帕金森病并伴有2型糖尿病的受试者年龄调整和研究年数调整的危害率，与那些没有得2型糖尿病的帕金森患者相比，分别是男人1.80（95％置信区间为1.03-3.15），女人为1.93（95％置信区间1.05-3.53），在男人和女人组合（因性别修正）中为1.85（95％置信区间为1.23-2.80）。进一步经体重指数修正，体循环压力，总胆固醇，教育水平，业余时间体育活动，吸烟，饮酒，咖啡和茶的消费情况仅仅轻微影响结果。2型糖尿病和帕金森病的危险性之间的多变量调节联系经分层亚组分析中也被证实。
CONCLUSIONS: These data suggest that type 2 diabetes is associated with an increased risk of Parkinson's disease. Surveillance bias might account for higher rates in diabetes. The mechanism behind this association between diabetes and Parkinson's disease is not known.
结论：这些数据认为2型糖尿病与帕金森病增加危险性有关。监督偏移可以解释糖尿病中较高的比率。糖尿病和帕金森病之间联系背后的机制还是未知的。


编译
目的：评价2型糖尿病是否是帕金森病的一个危险因子。实验设计和方法：我们前瞻性的随访作为基线的51552个25-74岁无帕金森病史的芬兰男人和女人.糖尿病史和其它研究参数通过标准化方法在基线被确定。帕金森病的确诊是根据全国性的社会保险协会的药物登记信息。伴有2型糖尿病的帕金森病人的危害率可以评价出来。 结果：在平均18.0年的随访时间中，324位男人和309位女人发展为帕金森病。患帕金森病并伴有2型糖尿病的受试者年龄调整和研究年数调整的危害率，与那些没有得2型糖尿病的帕金森患者相比，分别是男人1.80（95％置信区间为1.03-3.15），女人为1.93（95％置信区间1.05-3.53），在男人和女人组合（因性别修正）中为1.85（95％置信区间为1.23-2.80）。进一步经体重指数修正，体循环压力，总胆固醇，教育水平，业余时间体育活动，吸烟，饮酒，咖啡和茶的消费情况仅仅轻微影响结果。2型糖尿病和帕金森病的危险性之间的多变量调节联系经分层亚组分析中也被证实。 结论：这些数据认为2型糖尿病与帕金森病增加危险性有关。监督偏移可以解释糖尿病中较高的比率。糖尿病和帕金森病之间联系背后的机制还是未知的。